4 Best Spermidine Supplements [2022 Review]: Read BEFORE Buying

spermidine, which improves six of the nine known characteristics of aging. Aiding in the slowing or even reversal of biological aging.

There’s no question that spermidine is a wonder molecule. Not only does it improve health and extend lifespan, but it also reverses many of the signs of aging. In this blog post, we will explore some of the miraculous benefits of spermidine supplementation.

What is Spermidine

Spermidine is a polyamine (triamine) that plays a vital role in cellular metabolism. Originally identified in sperm, spermidine is derived from the amino acid ornithine and exists naturally in the body. Our food had plenty of spermidine before we became dependent on chemical agriculture. As we become older, our levels drop, and we age quicker as a result.

In a nutshell, spermidine is a fasting mimic with effects similar to calorie restriction, the gold standard for extending lifespan (described below). It works by enhancing the crucial process of cellular repair by activating AMPK (called autophagy). It also works as a signaling molecule and protects DNA and mitochondria, among other things (discussed below).

We can assist prevent spermidine deficit by eating spermidine-rich foods. However, unless you enjoy meals that are best described as “acquired tastes,” you’ll appreciate the convenience of spermidine pills.

This supplement has a high bioavailability and an excellent safety profile, according to studies. Participants in clinical studies have experienced no negative side effects, which is understandable given that it is contained naturally in the body. Some scientists believe…

The Best Spermidine Supplements of 2022

I believe in getting the most nutrients out of our food.

However, spermidine and other polyamines are notably lacking in Western cuisine. Many of the meals rich in it naturally (described below) are “acquired” tastes. I’d prefer to avoid certain textures and flavors.

That leaves supplements, at least for me.

However, because spermidine is produced by a few businesses, supplements are costly. More facilities will handle spermidine in the near future, and the existing premium will vanish. It was just a few years ago that it was exclusively accessible from research chemical suppliers.

Companies that offer spermidine will undoubtedly spring up all over the place. When choosing high-quality spermidine, keep the following in mind:

  • Dosage – the majority of trials have used 1mg, however up to 8mg per day appears to be safe.
  • GMO products concentrate toxins, and spermidine is derived from diverse meals.
  • Product compositions and doses should be based on the most recent research, according to the Scientific Advisory Board.
  • Junk – corporations scrimp and employ potentially dangerous excipients, flow agents, binders, and fillers, which you may avoid simply reading the label.
  • Facility — items should be manufactured in accordance with GMP and ISO9001 guidelines.
  • Powder, topical, tablet, and capsule forms of spermidine are available, each with its own set of benefits and drawbacks.

let’s go.


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Primeadine Overview

Primeadine Overview
Dose: 1mg spermidine
Spermidine Source: 910mg wheat-germ extract
Other Ingredients: FOS prebiotic fiber
Inactive Ingredients: Plant cellulose capsule
Manufactured In: USA
Servings: 30 (90 capsules total)
Ships To: Global
Price: $90 (save 10% with code URBAN10)
Best For: Stimulating the body’s natural production

Leslie Kenny invented Oxford Healthspan, one of the first commercially marketed spermidine supplements, after collaborating with leading Oxford experts. Their spermidine is derived from highly concentrated wheat germ from Japan.

The raw ingredients used by Oxford Healthspan meet the strict requirements of the Japan Health Food and Nutrition Food Association. Japan is well-known for its Nobel Prize-winning work in autophagy.

Primeadine’s recipe sets them different from the competition. To begin, they avoid using any synthetic substances or fillers. Many of these aren’t suitable for vegans. While Oxford Healthspan imports raw ingredients from Japan, the finished product is manufactured in an FDA-approved cGMP facility before being tested for purity.

They’ve also incorporated a special prebiotic fiber that nourishes the bacteria that produce spermidine in the intestines (Fuso- and Bacteroides). Taking spermidine supplements and instructing your body to make more naturally are two ways to boost your spermidine levels.

The supplement’s aesthetic-enhancing effects, such as thicker hair, quicker nail development, luminous complexion, decreased wrinkles, and stronger eyelashes, have been the emphasis of Primeadine’s promotion. Their claims have been supported by research. You’ll almost certainly come across real-world accounts of Primeadine improving beauty routines if you search the internet or chat to enough biohackers.

I took this spermidine supplement for the first time, and I still have numerous bottles on my shelf. Primeadine is the only supplement that boosts your body’s natural spermidine-producing bacteria.


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spermidineLIFE Overview

Dose: 1.5mg spermidine
Spermidine Source: 800mg wheat-germ extract
Other Ingredients: 1.5mg zinc, 0.2mg thiamine
Inactive Ingredients: Plant cellulose capsule, acetylated starch, calcium carbonate, magnesium stearate, glycerol
Manufactured In: Austria
Servings: 30 (60 capsules total)
Ships To: Global
Price: $99 (save 15% with code URBAN)
Best For: Used in real clinical research

Longevity Labs’ spermidineLIFE, based in Austria, is the other main spermidine brand, sponsored by some of the most well-known longevity experts. The distinguished Dr. David Sinclair (who popularized NMN and NR supplements), Guido Kroemer — the most referenced autophagy researcher, and many more make up their Scientific Advisory Board.

LIFE is the world’s first and only award-winning spermidine supplement, used by more than 80 international research teams. Most clinical research has utilized and depended on these items since their inception in 2019.

spermidineLIFE sells three products:

spermidineLIFE is a non-GMO, vegan-friendly wheat germ extract that is devoid of pollutants.

All of them contain the same 800mg wheat germ extract with 1mg spermidine.

Memory Plus also contains mood-boosting Saffron extract, as well as cognitive-enhancing vitamins and the Ayurvedic herb Brahmi.

Immunity Plus is a supplement that combines immunomodulatory vitamins and minerals, as well as adaptogenic shiitake mushrooms.

Do Not Age Spermidine

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Do Not Age Spermidine

Do Not Age Spermidine Overview

Dose: 4mg spermidine

Spermidine Source: 400mg wheat-germ extract

Other Ingredients: 1mg zinc

Inactive Ingredients: Cellulose

Manufactured In: UK

Servings: 60 (60 capsules total)

Ships To: Global

Price: $69 (save 10% with code URBAN)

Best For Guaranteed potency

Another well-known seller of longevity supplements is Do Not Age (DNA), situated in the United Kingdom. Their sirtuin-activating supplements are their most well-known product (SIRT6 activator in particular). According to Alan Graves, the company’s founder, developing high-quality yet cheap supplements is a top priority. Do Not Age researches the literature and polls their clients to choose which goods to provide. That is precisely what drove them to develop the most cost-effective spermidine.

This one stands out since it contains a whopping 4mg of spermidine in just 400mg of wheat germ extract. You’ll also receive 1mg of Zinc Picolinate. That’s 4X the strength of many other capsules in only one. All without straying into the gray zone of safety.

Do Not Age offers two sizes of vegan-friendly spermidine:

  • 60 capsules for $69
  • 366 capsules for $375

They manufacture spermidine in accordance with GMP and ISO9001 guidelines and then store it under ideal conditions.

Most firms lab test their goods before storing them in hot, light, humid warehouses, which causes the supplement to oxidize and deteriorate. Your typical spermidine product may have lost most of its efficacy by the time you receive it. DNA assures that you will receive the highest quality and purity on your doorstep, as with all of their products. They also ship internationally.

Do Not Age spermidine is the best overall value in terms of quality and potency.

Double Wood Spermidine

DoubleWood Spermidine Review
Double Wood Spermidine

Double Wood Spermidine Overview

Dose: 10mg spermidine

Spermidine Source: Putrescine

Other Ingredients: None

Inactive Ingredients: Plant cellulose capsule, rice flour

Manufactured In: Unknown

Servings: 60 (120 capsules total)

Ships To: Global

Price: $39.95

Best For Tight budgets

You’ve undoubtedly heard about Double Wood if you take longevity pills. They were the firm in charge of making the phenomenally successful NMN more accessible to the general public. Double Wood, for example, does not give nearly as much information about its procedures, purity, or safety tests.

They claim that their capsules are made and tested in the United States. The weight and heavy metal content are being tested in the lab. We have no idea what purity is. They’re also non-GMO and gluten-free, according to the label.

The majority of spermidine brands use wheat germ. Putrescine is used by Double Wood to make spermidine. We don’t know the bioavailability of Putrescine-derived spermidine or how the advantages compare because there hasn’t been much study done on it.

This is the strongest spermidine supplement I could locate, with 10mg per serving. That may appear tempting at first look. We don’t have any data on humans who consume 10mg or more of spermidine per day. It might be risk-free.

There are 120 capsules in each bottle. A serving consists of two capsules, each of which contains 5mg of spermidine. Rice flour is used as a filler in Double Wood.

Benefits of Spermidine

Spermidine Science Health Benefits

Potent autophaghy booster

Autophagy, a cellular maintenance mechanism, is greatly enhanced by spermidine. In addition, the mitochondria go through the same procedure (mitophagy).

The recycling of misfolded proteins and defective structures is thought to be the source of many of the most noteworthy advantages.

“Increased autophagic turnover of cytoplasmic organelles or long-lived proteins is implicated in most, if not all, life-prolonging treatments,” according to early 2010 spermidine study.


Inflammation has a part in almost all degenerative diseases.

Spermidine is widely recognized for its anti-inflammatory and anti-inflammatory properties (increases cytokine IL-10).

In mice, it “reduces inflammation-associated cytokines IFN-, IL-1, IL-6, and TNF-” as well as IL-12.

Spermidine also blocks the toxin LPS from causing inflammation. “Blocking the NF-B, PI3K/Akt, and MAPKs signaling pathways in microglia” is how it works.

This supplement can calm cytokine storms and halt the inflammatory cascade that causes a variety of diseases.

Circadian reset

Surprisingly, spermidine has the ability to regulate the circadian rhythm.

This supplement influences the expression of “clock genes” barely 60 minutes after consumption, according to a recent 2021 research. The benefits of autophagy are kicking in much faster.

The writers came at the following conclusion:

“…spermidine is a potent modulator of the circadian phase, acting through glucocorticoid receptor-independent pathways, and may be useful for treating diseases related to circadian desynchrony.”

Spermidine resets circadian clock phase in NIH3T3 cells

Improves cognitive function & slows decline

Prevents neurotoxicity

The impact of spermidine on brain toxicity has been studied in a few research.

A study of rats exposed to the poison sodium laurate was the most intriguing. The control group, as expected, acquired cerebral small vessel disease (CSVD). Among the pathological signs were:

  • Arterial damage
  • Mitochondrial impairment
  • Autophagic hyperactivity

Improves TBI recovery

In the year 2020, spermidine was linked to brain damage in mice.

TBI severity and spermidine level had a substantial inverse relationship, according to researchers.

The TBI will be worse if your spermidine level is low (and vice-versa).

The blood-brain barrier and the rate of neuronal cell death appear to be affected by spermidine. Spermidine production inhibition has a deleterious influence on neurobehavioral recovery.

Protects against degenerative disease

Protects mitochondria and telomeres

Spermidine has a significant impact on mitochondria.

Much of the anti-aging impact comes from increasing both autophagy and mitochondrial function, according to a 2020 study.

Another study found that when mitochondria were treated with a toxin, spermidine helped preserve them against aging and instability.

Mitophagy (autophagy in mitochondria) is a kind of autophagy that spermidine helps to enhance. It also boosts mitochondrial biogenesis, which is the process of producing new mitochondria.

Delays aging in humans

In other creatures, a spermidine study demonstrated that it reduced aging.

When yeast, worms, flies, and mice were fed spermidine-rich diets, they lived longer.

Then, in 2018, human studies (mainly epidemiological) discovered similar relationships.

In fact, levels of the polyamine family as a whole are linked to aging and illness. They also help you to be more resilient to stress.

The anti-aging action of spermidine is mediated through autophagy, geroprotection (DNA), AMPK activation, mitochondrial protection, and other processes.

Beauty (skin, hair, nails)

Spermidine not only helps you live longer, but it also enhances your skin, nails, and hair.

According to new research, spermidine is a promising cosmetic supplement for:

  • Skin elasticity
  • Skin hydration
  • Skin desquamation
  • Hair growth

Immune health

Spermidine boosts immunity in a variety of ways.

Inflammation and autophagy are also linked to immunity.

In one mouse research, spermidine was compared to the immunosuppressive yet widely used longevity medication rapamycin. As a result of sickness or immunization, older mice produce fewer antibodies. Giving these mice spermidine restored their T cell antibody response to normal levels, according to the researchers.

Improved T-cell and B-cell function, as well as a reduction in immune system overactivation, according to other studies (autoimmunity).

Promotes heart health

Spermidine plays an integral role in protecting the cardiovascular system.

Research has indicated that spermidine improves: